Mechanisms of Subcutaneous and Sublingual Aeroallergen Immunotherapy

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Immunological mechanisms of sublingual immunotherapy.

Administration of allergen-specific immunotherapy by the oral route, sublingual immunotherapy (SLIT), has been shown to be effective, with an improved safety profile compared with subcutaneous administration. However, the precise mechanisms underlying the induction of immune tolerance by SLIT remain unclear. Contact of the allergen with the antigen-presenting cells in oral mucosa is likely to b...

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Comparative efficacy and safety of subcutaneous versus sublingual immunotherapy.

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Subcutaneous and Sublingual Immunotherapy in Allergic Asthma in Children

This review presents up-to-date understanding of immunotherapy in the treatment of children with allergic asthma. The principal types of allergen immunotherapy (AIT) are subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT). Both of them are indicated for patients with allergic rhinitis and/or asthma, who have evidence of clinically relevant allergen-specific IgE, and significan...

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Cost of allergy immunotherapy: sublingual vs subcutaneous administration.

BACKGROUND Allergy immunotherapy is an effective way to manage the allergic patient and may be administered either through the subcutaneous route (SCIT) or the sublingual route (SLIT). Both have been proven efficacious; however, SLIT is currently not covered by insurance companies and is an out-of-pocket expense. The goal of the current study is to compare the costs of SCIT to SLIT. METHODS F...

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ژورنال

عنوان ژورنال: Immunology and Allergy Clinics of North America

سال: 2020

ISSN: 0889-8561

DOI: 10.1016/j.iac.2019.09.009